Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth.
Leanna M Hernandez,
Minsoo Kim,
Pan Zhang,
Richard A I Bethlehem,
Gil Hoftman,
Robert Loughnan,
Diana Smith,
Susan Y Bookheimer,
Chun Chieh Fan,
Carrie E Bearden,
Wesley K Thompson,
Michael J Gandal
Apr 07, 2023
Background
Increased expression of the complement component 4A (C4A) gene is associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in synaptic pruning; yet, it remains unclear the extent...